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Bcl-2 Family

Bcl-2 family proteins are a group of proteins homologous to the Bcl-2 protein and characterized by containing at least one of four conserved Bcl-2 homology (BH) domains (BH1, BH2, BH3 and BH4). Bcl-2 family proteins, consisting of pro-apoptotic and anti-apoptotic molecules, can be classified into the following three subfamilies according to sequence homology within four BH domains: (1) a subfamily shares sequence homology within all four BH domains, such as Bcl-2, Bcl-XL and Bcl-w which are anti-apoptotic; (2) a subfamily shares sequence homology within BH1, BH2 and BH4, such as Bax and Bak which are pro-apoptotic; (3) a subfamily shares sequence homology only within BH3, such as Bik and Bid which are pro-apoptotic.

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  1. Cat.No. Product Name Information
  2. A3935 WEHI-539

    WEHI-539 is a small-molecule inhibitor of BCLXLwith an IC50 value of 1.1 nM .

  3. B6094 BH3I-1
  4. A8737 S63845

    S63845 is a small molecule MCL1 inhibitor with Ki < 1.2 nM [1].

  5. B6011 A-1210477
  6. B5978 BDA-366 BDA-366 is a selective antagonist of BCL2 BH4 domain with Ki value of 3.3 nM [1].
  7. B5846 Radotinib(IY-5511) Radotinib(IY-5511) is a novel and selective Bcl-Abl tyrosine kinase inhibitor. [1]
  8. B4902 (+)-Apogossypol
  9. B4901 Pyridoclax
  10. B4881 UMI-77
  11. A9902 Bcl Family Set I ABT-737 is a BH3 mimetic inhibitor of Bcl-xL (EC50=78.7 nM), Bcl-2 (EC50=30.3 nM) and Bcl-w (EC50=197.8 nM), respectively.

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