MTH1 (human MutT homolog 1) is an antimutagenic purine nucleoside triphosphatase that sanitize oxidized nucleotide pools. It protects the cell from oxidative stress-induced cell dysfunction or death. It is a target for anticancer treatment.
- Cat.No. Product Name Information
(S)-crizotinibthe selectively inhibited MTH1 catalytic activity with IC50 of 72 nM, while clinically used (R)-enantiomer of the drug was inactive with IC50 of 1375 nM.
- B5849 TH287 TH287 is a potent MTH1 inhibitor with IC50 of 0.8±0.1 nM. 
- B5845 TH588 TH588 is a potent and selective MTH1 inhibitor (IC50 = 5 nM)
- B4935 SCH 51344