PKC (protein kinase C) is a serine/threonine protein kinase that mediates insulin signaling, actin cytoskeleton, cell mobility, apoptosis and tumorigenesis etc.
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Staurosporine, an alkaloid produced in Streptomyces staurospores originally as an antifungal agent, is an inhibitor of a broad spectrum of protein kinases, including protein kinase C (PKC), Camp-dependent protein kinase (PKA), phosphorylase kinase, ribosomal protein S6 kinase, epidermal growth factor receptor (EGF-R) kinase and Ca2+/calmodulin-dependent protein kinase II (Ca/CaM PKII). The inhibition potency is strongest for PKC (IC50 = 2.7 nM) but several-fold lower for other protein kinases.
- C4885 1,2-Dimyristoyl-sn-glycerol
- C4882 1,2-Dilauroyl-sn-glycerol
- C4877 1,2-Distearoyl-sn-glycerol
- C5388 Hexadecyl Methyl Glycerol
- C4829 UCN-02
- C4703 1,2-Dipalmitoyl-sn-glycerol
- C4717 L-threo-Sphingosine C-18
- C4315 Bisindolylmaleimide VIII (acetate)
- C4316 Bisindolylmaleimide IV