4A3-SC8
Catalog No.
M2010
4A3-SC8 is a modular degradable dendrimer. It enables small RNAs to extend survival in an aggressive liver cancer model.
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4A3-SC8 is an ionizable cationic lipid (pKa = 6.66) and a dendrimer that is widely used in the generation of lipid nanoparticles (LNPs) for the delivery of siRNA, mRNA, single-guide RNA (sgRNA), single-stranded DNA (ssDNA), and PEGylated BODIPY dyes. LNPs containing 4A3-SC8 can encapsulate siRNA targeting Factor VII, selectively accumulate in the liver, and effectively reduce hepatic Factor VII activity in mice. Additionally, intravenous administration of these LNPs encapsulating an mRNA reporter and PEGylated BODIPY dye has been successfully applied in tumor imaging studies in mice.
| Storage | Store at -20°C |
| M.Wt | 1467.18 |
| Cas No. | 1857340-78-3 |
| Formula | C75H139N3O16S4 |
| Solubility | ≥40.1 mg/mL in DMSO; ≥43.2 mg/mL in EtOH; ≥33.5 mg/mL in H2O |
| SDF | Download SDF |
| Canonical SMILES | CCCCCCCCSCC(C)C(OCCOC(CCN(CCC(OCCOC(C(CSCCCCCCCC)C)=O)=O)CCCN(C)CCCN(CCC(OCCOC(C(C)CSCCCCCCCC)=O)=O)CCC(OCCOC(C(C)CSCCCCCCCC)=O)=O)=O)=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
