Acamprosate calcium
Acamprosate calcium is a synthetic drug for abstinence of patients with alcohol dependence [1].
Acamprosate administration can reduce alcohol intake. In rat model, oral acamprosate at dose of 50 to 400 mg/kg/day reduced voluntary oral ethanol consumption dose-dependently. However, the exact cellular target and mechanism of acamprosate is not clear. Acamprosate has a structure similar to that of GABA. It can specifically bind to GABAB receptors but not GABAA receptors. Besides that, acamprosate showed serotonergic properties. It increased 5-HT levels and the effects caused by 5-HT in rats exposed to ethanolvapour. Moreover, acamprosate was thought to have effects on inhibiting the excitatory activity of aminoacid and reducing Ca2+fluxes [1].
References:
1. Wilde M I, Wagstaff A J. Acamprosate. Drugs, 1997, 53(6): 1038-1053.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 400.48 |
| Cas No. | 77337-73-6 |
| Formula | C10H20CaN2O8S2 |
| Synonyms | Calcium N-acetylhomotaurinate; Campral EC |
| Solubility | ≥40 mg/mL in H2O; insoluble in DMSO; insoluble in EtOH |
| Chemical Name | calcium;3-acetamidopropane-1-sulfonate |
| SDF | Download SDF |
| Canonical SMILES | CC(=O)NCCCS(=O)(=O)[O-].CC(=O)NCCCS(=O)(=O)[O-].[Ca+2] |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
