Angiotensin 1/2 (1-7) amide
Angiotensin I/II (1-7) amide (H2N-Asp-Arg-Val-Tyr-Ile-His-Pro-amide) is a peptide analog to angiotensin II that is used as a vasopressor in the treatment of certain types of shock and circulatory collapse.
Angiotensin II (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe | His-Leu) is an octapeptide that is converted from Angiotensin I (AI) through the removal of two C-terminal residues by angiotensin-converting enzyme (ACE), primarily by ACE within the lung (but also those present in endothelial and kidney epithelial cells). Ang-(1–7) is an endogenous peptide fragment that can be produced from Ang I or Ang II via endo- or carboxy-peptidases respectively. [1]
Angiotensin I/II (1-7) amide is an amide derivative of angiotensin II that is a powerful vasoconstrictor and vasopressor, and is used in the treatment of certain hypotensive states. Angiotensin I/II (1-7) amide is usually administered by slow intravenous infusion, and sometimes intramuscularly or subcutaneously.
Fig. 1: Formula of Angiotensin I/II (1-7) amide
Ref:
1. Santos et al (2000) Angiotensin-(1-7): an update. Regul.Pept. 91 45.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 898.02 |
| Formula | C41H63N13O10 |
| Synonyms | H2N-Asp-Arg-Val-Tyr-Ile-His-Pro-amide |
| Solubility | insoluble in EtOH; ≥12.1 mg/mL in H2O; ≥89.8 mg/mL in DMSO |
| SDF | Download SDF |
| Canonical SMILES | O=C(N)[C@@H]1N(C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC)=O)CCCNC(N)=N)=O)C)=O)CC2=CC=C(O)C=C2)=O)[C@@H](C)CC)=O)CC3=CNC=N3)=O)CCC1 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
