beta-Nicotinamide mononucleotide
beta-Nicotinamide mononucleotide (β-NMN) is an intermediate in the biosynthesis of nicotinamide adenine dinucleotide[1].
In a Nampt+/- mouse model of metabolic disease, β-NMN (50-100 µM) has been used to enhance NAD biosynthesis and glucose-stimulated insulin secretion, demonstrating a role for Nampt in β cell function[2].
Furthermore, at 500 mg/kg/day, β-NMN has been shown to ameliorate glucose intolerance in high-fat diet-induced type 2 diabetes mice by restoring NAD+ levels[3].
References:
[1]. Gallí M, Van Gool F, Rongvaux A, et al. The nicotinamide phosphoribosyltransferase: A molecular link between metabolism, inflammation, and cancer. Cancer Research, 2010, 70: 8-11.
[2]. Revollo J R, Körner A, Mills K F, et al. Nampt/PBEF/visfatin regulates insulin secretion in Β cells as a systemic NAD biosynthetic enzyme. Cell Metabolism, 2007, 6(5): 363-375.
[3]. Yoshino J, Mills K F, Yoon M J, et al. Nicotinamide mononucleotide, a key NAD+ intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice. Cell Metabolism, 2011, 14(4): 528-536.
- 1. Joshua Reeves, ProfilePierre Tournier, et al. "Rejuvenating aged osteoprogenitors for bone repair." bioRxiv. December 04, 2024.
- 2. Yan Wang, Si Liu, et al. "Nicotinamide Mononucleotide (NMN) Ameliorates Free Fatty Acid-Induced Pancreatic β-Cell Dysfunction via the NAD+/AMPK/SIRT1/HIF-1α Pathway." Int J Mol Sci. 2024 Sep 30;25(19):10534. PMID: 39408861
- 3. Wencui Wan, Wei Zhu, et al. "Grape Seed Proanthocyanindin Extract Moderated Retinal Pigment Epithelium Cellular Senescence Through NAMPT/SIRT1/NLRP3 Pathway." J Inflamm Res. 2021 Jul 12;14:3129-3143. PMID: 34285539
- 4. Keke Wu, Biao Li, et al. "Nicotinamide mononucleotide attenuates isoproterenol-induced cardiac fibrosis by regulating oxidative stress and Smad3 acetylation." Life Sci. 2021 Mar 3;274:119299. PMID: 33675899
- 5. Nima Nalin. "Nicotinamide mononucleotide imparts protection against Doxorubicin-induced cardiotoxicity by maintaining lysosomal acidification." The University of Western Ontario.
- 6. Peng, Tianqing. "Nicotinamide mononucleotide imparts protection against Doxorubicin-induced cardiotoxicity by maintaining lysosomal acidification." Western University, 8-4-2020.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 334.22 |
| Cas No. | 1094-61-7 |
| Formula | C11H16N2O8P |
| Solubility | ≥33.4 mg/mL in H2O; insoluble in EtOH; insoluble in DMSO |
| Chemical Name | ((2R,3S,4R,5R)-3,4-dihydroxy-5-(3-(hydroxy(imino)methyl)pyridin-1-ium-1-yl)tetrahydrofuran-2-yl)methyl hydrogen phosphate |
| SDF | Download SDF |
| Canonical SMILES | N=C(O)C1=C[N+]([C@@]2([H])[C@@](O)([H])[C@@](O)([H])[C@@](O2)([H])COP(O)([O-])=O)=CC=C1 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Cell experiment:[1] | |
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Cell lines |
Primary islets isolated from Nampt+/- and control female mice |
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Reaction Conditions |
50 μM NMN for overnight incubation |
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Applications |
The addition of NMN significantly augmented insulin secretion in response to 20 mM glucose in both Nampt+/- and control islets, and after NMN treatment, glucose-stimulated insulin secretion (GSIS) did not differ between Nampt+/- and control islets. |
| Animal experiment:[1] | |
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Animal models |
Nampt+/- female mice |
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Dosage form |
500 mg/kg Injected intraperitoneally ~ 14 h prior to intraperitoneal glucose tolerance tests (i.p. GTTs) |
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Applications |
After NMN administration, there was no difference in blood glucose levels in i.p. GTTs between Nampt+/- and control female mice. In addition, NMN-treated Nampt+/- and control mice also had similar plasma insulin levels at each time point. These data clearly indicate that NMN administration corrects the defect in GSIS observed in Nampt+/- mice. |
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Note |
The technical data provided above is for reference only. |
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References: 1. Revollo J R, Körner A, Mills K F, et al. Nampt/PBEF/visfatin regulates insulin secretion in Β cells as a systemic NAD biosynthetic enzyme. Cell Metabolism, 2007, 6(5): 363-375. |
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Quality Control & MSDS
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Chemical structure
