Biperiden HCl
Biperiden HCl is an anticholinergic drug [1].
As an anticholinergic drug, biperiden is first used in the treatment of Parkinson's disease. It is a competitive antagonist of muscarinic receptor. It has been believed that in the patients of PD, a reduction of intranigral dopamine concentrations results in a relative imbalance between the dopaminergic and cholinergic neurological pathways. The anticholinergics can correct the imbalance through reducing the degree of neurotransmission mediated by neostriatal acetylcholine. Biperiden is also used to treat extrapyramidal side effects of antipsychotic drugs. In addition, the misuse of biperiden causing delirium has been reported in several clinical settings [1, 2].
References:
[1] Brocks D R. Anticholinergic drugs used in Parkinson’s disease: an overlooked class of drugs from a pharmacokinetic perspective. J Pharm Pharm Sci, 1999, 2(2): 39-46.
[2] Espi Martinez F, Espi Forcen F, Shapov A, et al. Biperiden Dependence: Case Report and Literature Review. Case reports in psychiatry, 2012, 2012.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 347.92 |
| Cas No. | 1235-82-1 |
| Formula | C21H30ClNO |
| Solubility | insoluble in H2O; ≥8.27 mg/mL in EtOH with ultrasonic; ≥8.7 mg/mL in DMSO |
| Chemical Name | 1-(5-bicyclo[2.2.1]hept-2-enyl)-1-phenyl-3-piperidin-1-ylpropan-1-ol;hydrochloride |
| SDF | Download SDF |
| Canonical SMILES | C1CCN(CC1)CCC(C2CC3CC2C=C3)(C4=CC=CC=C4)O.Cl |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Animal experiment : | |
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Animal models |
Male Lister Hooded rats model; |
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Dosage form |
3, and 10 mg/kg; intraperitoneal injection; for 90 min; or 4 mg, oral administration |
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Applications |
Biperiden HCl acted as cognition impairer in rats and Biperiden (10 mg/kg) induced side-effects, with rats taking more time to start the task [1]. Moreover, oral doses of 4 mg of Biperiden HCl reached a Cmax of approximately 4 ng/mL [2]. |
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Other notes |
Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal. |
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References: 1. Szczodry, O., van der Staay, F. J. and Arndt, S. S. (2014) Modelling Alzheimer-like cognitive deficits in rats using biperiden as putative cognition impairer. Behav Brain Res. 274, 307-311 2. Brocks, D. R. (1999) Anticholinergic drugs used in Parkinson's disease: An overlooked class of drugs from a pharmacokinetic perspective. J Pharm Pharm Sci. 2, 39-46 |
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