BRL-15572
BRL-15572 is an antagonist of 5-HT1D receptor with pKi value of 7.9 [1].
In the in vitro binding assay, BRL-15572 shows 60-fold higher affinity for human 5-HT1D receptor than for h5-HT1B receptor. However, it also has moderately high affinity at both human 5-HT1A and human 5-HT2B receptors. It limits the use of BRL-15572 as a pharmacological tool in systems. In native tissue, BRL-15572 totally inhibits [3H] 5-CT specific binding in guinea-pig striatum. In the functional assays, BRL-15572 is potent at both [35S] GTPγS binding assay and cAMP accumulation assay. It shows a pEC50 value of 8.1 at h5-HT1D receptor expressed in CHO cell membranes. And the activity shows to be lower in the cAMP assay [1].
References:
[1] Price G W, Burton M J, Collin L J, et al. SB-216641 and BRL-15572–compounds to pharmacologically discriminate h5-HT1B and h5-HT1D receptors. Naunyn-Schmiedeberg's archives of pharmacology, 1997, 356(3): 312-320.
| Storage | Store at -20°C |
| M.Wt | 478.13 |
| Cas No. | 193611-72-2 |
| Formula | C25H27ClN2O·ClH·ClH |
| Solubility | Soluble in DMSO |
| Chemical Name | 3-[4-(3-chlorophenyl)piperazin-1-yl]-1,1-diphenylpropan-2-ol;dihydrochloride |
| SDF | Download SDF |
| Canonical SMILES | C1CN(CCN1CC(C(C2=CC=CC=C2)C3=CC=CC=C3)O)C4=CC(=CC=C4)Cl.Cl.Cl |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Description | BRL-15572 is an antagonist of 5-HT1D receptor with a pKi value of 7.9. | |||||
| Targets | 5-HT1D | 5-HT1A | 5-HT2B | 5-HT2A | 5-HT7 | |
| IC50 | 7.9(pKi) | 7.7(pKi) | 7.4(pKi) | 6.6(pKi) | 6.3(pKi) | |
Quality Control & MSDS
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Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
- Datasheet
Chemical structure
