Bromfenac Sodium
Bromfenac is a nonsteroidal anti-inflammatory drug (NSAID), which has anti-inflammatory activity and may block prostaglandin synthesis by inhibiting cyclooxygenase 1 and 2.
| Storage | Store at -20°C |
| M.Wt | 356.15 |
| Cas No. | 91714-93-1 |
| Formula | C15H11BrNO3·Na |
| Solubility | insoluble in EtOH; ≥14.7 mg/mL in DMSO; ≥26.85 mg/mL in H2O |
| Chemical Name | sodium;2-[2-amino-3-(4-bromobenzoyl)phenyl]acetate |
| SDF | Download SDF |
| Canonical SMILES | C1=CC(=C(C(=C1)CC(=O)[O-])N)C(=O)C2=CC=C(C=C2)Br.[Na+] |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Cell experiment [1]: | |
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Cell lines |
Corneal epithelial cells |
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Preparation method |
The solubility of this compound in DMSO is > 14.7 mg/mL. General tips for obtaining a higher concentration: Please warm the tube at 37 °C for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below - 20 °C for several months. |
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Reacting condition |
1, 4, 12, 24 and 48 hrs |
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Applications |
Compared with Bromfenac Sodium, the cellular metabolic activity of Diclofenac and Fluorometholone markedly decreased after 12-hr exposure. However, the K+ and Cl- concentrations, pH and osmolarity were similar among different treatment groups. In additioin, Bromfenac Sodium significantly promoted cell migration, as well as restored wound gap after 48-hr exposure, compared with Diclofenac and Fluorometholone. |
| Animal experiment [2]: | |
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Animal models |
A rabbit model of ocular inflammation |
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Dosage form |
50 μL 0.09% |
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Applications |
In a rabbit model of ocular inflammation, Bromfenac Sodium almost completely inhibited lipopolysaccharide (LPS)-induced increases in fluorescein isothiocyanate (FITC)-dextran in the anterior chamber as well as the contralateral eye. In addition, Bromfenac Sodium significantly inhibited LPS-induced increases in PGE2 concentrations in the aqueous humor. |
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Other notes |
Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal. |
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References: [1]. Lee JS, Kim YH, Park YM. The Toxicity of Nonsteroidal Anti-inflammatory Eye Drops against Human Corneal Epithelial Cells in Vitro. J Korean Med Sci. 2015 Dec;30(12):1856-64. [2]. Waterbury LD, Silliman D, Jolas T. Comparison of cyclooxygenase inhibitory activity and ocular anti-inflammatory effects of ketorolac tromethamine and bromfenac sodium. Curr Med Res Opin. 2006 Jun;22(6):1133-40. | |
Quality Control & MSDS
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Chemical structure
