Cardiogreen
Cardiogreen, also known as indocyanine green, is a nontoxic tricarbocyanine dye, with a peak spectral absorption at 790 nm. Cardiogreen administered intravenously rapidly binds to its principle carrier, plasma protein, and then becomes confined to the vascular space. Cardiogreen has been commonly used in medical diagnostics for measuring cardiac output, liver blood flow, and hepatic function, as well as for ophthalmic angiography. In addition, cardiogreen can also be used as a photosensitizer in the photodynamic therapy (PDT) for treating diseases like periodontal infections.
References:
1. "Indocyanine green solution". NIH. National Cancer Institute. Retrieved 20 August 2021.
2. Gharesi S, Pourhajibagher M, Chiniforush N, et al. Effect of photodynamic therapy based on indocyanine green on expression of apoptosis-related genes in human gingival fibroblast cells. Photodiagnosis and Photodynamic Therapy , 2017, 19: 33-36.
| Storage | Store at -20°C |
| M.Wt | 774.96 |
| Cas No. | 3599-32-4 |
| Formula | C43H47N2NaO6S2 |
| Synonyms | Foxgreen; IC Green; Indocyanine green |
| Solubility | insoluble in EtOH; ≥17.17 mg/mL in H2O; ≥27.65 mg/mL in DMSO |
| Chemical Name | sodium 4-(2-((1E,3E,5E,7E)-7-(1,1-dimethyl-3-(4-sulfonatobutyl)-1H-benzo[e]indol-2(3H)-ylidene)hepta-1,3,5-trien-1-yl)-1,1-dimethyl-1H-benzo[e]indol-3-ium-3-yl)butane-1-sulfonate |
| SDF | Download SDF |
| Canonical SMILES | O=S(CCCCN(C1=C(C/2(C)C)C3=CC=CC=C3C=C1)C2=C\C=C\C=C\C=C\C4=[N+](CCCCS([O-])(=O)=O)C5=C(C6=CC=CC=C6C=C5)C4(C)C)([O-])=O.[Na+] |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Cell experiment:[2] | |
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Cell lines |
Human gingival fibroblast (HGF) cells |
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Reaction Conditions |
1000 μg/mL cardiogreen for 5 min incubation |
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Applications |
Cardiogreen PDT with the exposure time of 60s for the diode laser would appear to be an inducer of apoptosis in HGF cells at transcriptome level. |
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Note |
The technical data provided above is for reference only. |
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References: 1. "Indocyanine green solution". NIH. National Cancer Institute. Retrieved 20 August 2021. 2. Gharesi S, Pourhajibagher M, Chiniforush N, et al. Effect of photodynamic therapy based on indocyanine green on expression of apoptosis-related genes in human gingival fibroblast cells. Photodiagnosis and Photodynamic Therapy , 2017, 19: 33-36. |
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Quality Control & MSDS
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Chemical structure
