Cyproheptadine hydrochloride
Cyproheptadine hydrochloride is an antagonist of serotonin receptor [1].
Cyproheptadine is a serotonin and histamine antagonist as well as an antimuscarinic reagent. It is used to treat for postgastrectomy-dumping syndrome, pruritic dermatoses, migraine, anorexia, and pituitary-dependent Cushing's syndrome. The major urinary product of cyproheptadine is cyproheptadine glucuronide, a quaternary ammonium compound. Cyproheptadine has some side effects including sedation, drowsiness, hypotension, tachycardia and blood dyscrasias. As a 5-HT2A receptor antagonist, cyproheptadine is found to reverse serotonin-enhanced ADP-induced platelet aggregation in vitro and ex vivo suggesting its antiplatelet and thromboprotective effects. [1, 2]
References:
[1] Levine B, Green-Johnson D, Hogan S, Smialek JE. A cyproheptadine fatality. J Anal Toxicol. 1998 Jan-Feb;22(1):72-4.
[2] Lin OA, Karim ZA, Vemana HP, Espinosa EV, Khasawneh FT. The antidepressant 5-HT2A receptor antagonists pizotifen and cyproheptadine inhibit serotonin-enhanced platelet function. PLoS One. 2014 Jan 23;9(1):e87026.
| Physical Appearance | A solid |
| Storage | Desiccate at -20°C |
| M.Wt | 323.86 |
| Cas No. | 969-33-5 |
| Formula | C21H22ClN |
| Solubility | insoluble in H2O; ≥32.39 mg/mL in DMSO; ≥12.14 mg/mL in EtOH |
| Chemical Name | 4-(dibenzo[1,2-a:1',2'-e][7]annulen-11-ylidene)-1-methylpiperidine;hydrochloride |
| SDF | Download SDF |
| Canonical SMILES | CN1CCC(=C2C3=CC=CC=C3C=CC4=CC=CC=C42)CC1.Cl |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
- View current batch:
Chemical structure
