Digoxin
Digoxin effectively inhibits Na+/K+-ATPase and has the potential to treat arrhythmias and heart failure[1].
Digoxin treatment can reduce CHIKV infection of U-2 OS cells, primary human synovial fibroblasts (HSF), and Vero African green monkey kidney cells. Twenty-four hours after treatment with 1 μM digoxin, cell survival is only moderately compromised, which is 20 times the digoxin EC50 dose of the antiviral activity of CHIKV in these cells [1].
Reference:
[1]. Ashbrook A W, et al. Antagonism of the Sodium-Potassium ATPase Impairs Chikungunya Virus Infection. MBio, 2016, 7(3): e00693-16.
| Physical Appearance | A solid |
| Storage | Store at RT |
| M.Wt | 780.94 |
| Cas No. | 20830-75-5 |
| Formula | C41H64O14 |
| Solubility | ≥33.25 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH |
| SDF | Download SDF |
| Canonical SMILES | O[C@]1([C@]([C@@H](C2=CC(OC2)=O)CC1)(C)[C@@H]3O)[C@H]4[C@H](C3)[C@](CC[C@@H]5O[C@@H](C[C@@H]6O)O[C@H](C)[C@H]6O[C@@H](C[C@@H]7O)O[C@H](C)[C@H]7O[C@@H](C[C@@H]8O)O[C@H](C)[C@H]8O)(C)[C@@H](C5)CC4 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Cell experiment:[1] | |
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Cell lines |
Human osteosarcoma (U-2 OS) cells |
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Reaction Conditions |
0.01 ~ 10 μM digoxin for 1 h incubation |
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Applications |
Treatment of human cells with digoxin resulted in a dose-dependent decrease in infection by chikungunya virus (CHIKV). Inhibition by digoxin was cell type-specific, as digoxin treatment of either murine or mosquito cells did not diminish CHIKV infection. |
| Animal experiment:[2] | |
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Animal models |
Female mongrel dogs in which the main pulmonary artery had been constricted progressively until cardiac failure developed |
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Dosage form |
1 ~ 1.2 mg Administered intravenously |
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Applications |
Acute digoxin treatment decreased right atrial pressure and increased cardiac output in a canine model of congestive heart failure produced by pulmonary artery constriction |
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Note |
The technical data provided above is for reference only. |
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References: 1. Ashbrook AW, Lentscher AJ, Zamora PF, et al. Antagonism of the Sodium-Potassium ATPase Impairs Chikungunya Virus Infection. mBio, 2016, 7(3): e00693-16. 2. Davis JO, Howell DS, Hyatt RE. Effects of acute and chronic digoxin administration in dogs with right-sided congestive heart failure produced by pulmonary artery constriction. Circulation Research. 1955, 3(3): 259-263. |
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