DiscoveryProbe™ Angiogenesis Library
Catalog No.
L1047
A unique collection of 84 small molecule compounds for angiogenesis research.
Featured Products
| Catalog No. | Product Name | Summary | Targets | CAS Number | Smiles |
| A3001 | PCI-32765 (Ibrutinib) | Bruton's tyrosine kinase (BTK) inhibitor | BTK | 936563-96-1 | C=CC(=O)N1CCCC(C1)N2C3=C(C(=N2)C4=CC=C(C=C4)OC5=CC=CC=C5)C(=NC=N3)N |
| A3302 | CGI-1746 | Btk inhibitor | BTK | 910232-84-7 | CC1=C(C=CC=C1NC(=O)C2=CC=C(C=C2)C(C)(C)C)C3=CN(C(=O)C(=N3)NC4=CC=C(C=C4)C(=O)N5CCOCC5)C |
| A4506 | DMOG | Competitive HIF-PH inhibitor, cell-permeable | HIF | 89464-63-1 | COC(=O)CNC(=O)C(=O)OC |
| A8164 | Cyclo (-RGDfK) | Inhibitor of αvβ3 integrin | Integrin | 161552-03-0 | C1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CCCN=C(N)N)CCCCN)CC2=CC=CC=C2)CC(=O)O |
| A8233 | DMXAA (Vadimezan) | Tumnor vascular disrupting agent, apoptosis inducer | VDA | 117570-53-3 | CC1=C(C2=C(C=C1)C(=O)C3=C(O2)C(=CC=C3)CC(=O)O)C |
| A8660 | Cilengitide | Integrin inhibitor for αvβ3 and αvβ5 | Integrin | 188968-51-6 | CC(C)C1C(=O)NC(C(=O)NCC(=O)NC(C(=O)NC(C(=O)N1C)CC2=CC=CC=C2)CC(=O)O)CCCN=C(N)N |
| B3708 | RGD (Arg-Gly-Asp) Peptides | Inhibits integrin binding to RGD motifs | Integrin | 99896-85-2 | C(CC(C(=O)NCC(=O)NC(CC(=O)O)C(=O)O)N)CN=C(N)N |
| B6004 | PX-478 2HCl | HIF-1α inhibitor | HIF | 685898-44-6 | ClCC[N+](C1=CC=C(C[C@@](N)([H])C(O)=O)C=C1)([O-])CCCl.Cl.Cl |
Related Biological Data
In the Burkitt lymphoma cell line Namalwa, the anti-IgM–induced phosphorylation of protein kinase B (PKB/AKT) and ERK were inhibited by PCI-32765 , whereas phosphorylation of the activating LYN/SYK substrate site Y551 of BTK was actually upregulated.
Review (University of Minnesota)
Fura-2 loaded purified basophils were incubated with vehicle control (0.0005% DMSO) or 50 nM PCI-32765 for 10 minutes prior to the addition of 0.5 μg/ml anti-IgE antibody and the cytosolic calcium response monitored. The 350/380 excitation ratio is plotted for the average of two experiments.
Review (Thomas Jefferson University)
Src expression in BMMs cultured with RANKL and M-CSF for 3 days in the presence of ibrutinib at indicated concentration.
Related Biological Data
Related Biological Data
Related Biological Data
| Form | Pre-dissolved DMSO solutions | Stability | Solution: -20°C for 12 months, -80°C for 24 months |
| Packaging | 96-well rack with Matrix 2D Barcoded ScrewTop Storage tubes (250 μL or 100 μL/well, 10 mM DMSO). 96-well DeepWell format with peelable foil seal and EVA cap (100 μL/well, 10 mM DMSO). |
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| Shipping Condition | Evaluation sample solution: ship with blue ice All other available size: ship with RT, or blue ice upon request |
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-- Available in stock with overnight delivery and free shipping over $500.
-- Cost-effective and competitive price to save your budget.
-- Potent, selective and cell-permeable in inhibiting or activating target molecules.
-- Diverse in chemical structure and route of administration (oral/i.m/i.v injection etc.)
-- Detailed files describing potency, selectivity and applications etc.
-- Supported by published data from top peer-reviewed journals.
-- Guaranteed high quality with NMR and HPLC validation.
