FR 180204
Catalog No.
A8304
ERK inhibitor
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Selective ERK inhibitor (IC50 values are 0.14 and 0.31 μM for ERK2 and ERK1 respectively). Displays 30-fold selectivity for ERK over p38α (IC50 = 10 μM); displays no activity against human recombinant MEK1, MKK4, IKKα, PKCα, Src, Syc and PDGFα at concentrations less than 30 μM. Also inhibits TGFβ-induced AP-1 activation in Mv1Lu cells (IC50 = 3.1 μM).
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 327.34 |
| Cas No. | 865362-74-9 |
| Formula | C18H13N7 |
| Solubility | insoluble in H2O; ≥10.25 mg/mL in DMSO; ≥4.47 mg/mL in EtOH with ultrasonic |
| Chemical Name | 5-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-amine |
| SDF | Download SDF |
| Canonical SMILES | C1=CC=C(C=C1)C2=NN3C=CC=CC3=C2C4=NN=C5C(=C4)C(=NN5)N |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
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