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In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Animal models
Male New Zealand rabbits with a mean body weight of 2300 ± 300 g
Dosage form
2000 IU heparin
Administered by the intravenous route (i.v.)
Applications
Heparin increased both anti-factor Xa activity and activated partial thromboplastin time (aPTT). Heparin (2000 IU, i.v.) showed an AUC0→24/kg value of 3.30 ± 0.59 IU·h-1·mL-1·kg-1, with 100% absolute bioavailability. Apart from the parenteral route, heparin could also be administered by the oral route when incorporated into polymeric nanoparticles which were able to maintain the anti-Xa activity of heparin for a longer period.
Note
The technical data provided above is for reference only.
References:
1. Jiao Y, Ubrich N, Marchand-Arvier M, et al. In vitro and in vivo evaluation of oral heparin-loaded polymeric nanoparticles in rabbits. Circulation, 2002, 105(2): 230-235.