Ibutilide Fumarate
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 885.23 |
| Cas No. | 122647-32-9 |
| Formula | (C20H36N2O3S)2·C4H4O4 |
| Solubility | ≥25.6 mg/mL in DMSO; ≥16.4 mg/mL in H2O with ultrasonic; ≥2.69 mg/mL in EtOH with ultrasonic |
| Chemical Name | (E)-but-2-enedioic acid;N-[4-[4-[ethyl(heptyl)amino]-1-hydroxybutyl]phenyl]methanesulfonamide |
| SDF | Download SDF |
| Canonical SMILES | CCCCCCCN(CC)CCCC(C1=CC=C(C=C1)NS(=O)(=O)C)O.CCCCCCCN(CC)CCCC(C1=CC=C(C=C1)NS(=O)(=O)C)O.C(=CC(=O)O)C(=O)O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Cell experiment [1]: | |
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Cell lines |
Neonatal rat cardiomyocytes |
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Preparation method |
The solubility of this compound in DMSO is >10 mM. General tips for obtaining a higher concentration: Please warm the tube at 37℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months. |
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Reacting condition |
10-8 to 10-3 mol/L for 4-12 h |
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Applications |
Ibutilide protected against H2O2-induced cardiomyocytes injury through inhibiting endoplasmic reticulum and mitochondrial stress pathways. |
| Animal experiment [2]: | |
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Animal models |
Open-chest beagles model |
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Dosage form |
10 μg/kg, intravenous administration, for 10 min; 0.1 mg/kg/h |
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Applications |
Ibutilide significantly decreased defibrillation threshold through the reduction of activation pattern complexity during ventricular fibrillation in canine hearts. |
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Other notes |
Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal. |
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References: 1. Wang, Y., Wang, Y. L., Huang, X., Yang, Y., Zhao, Y. J., Wei, C. X. and Zhao, M. (2016) Ibutilide protects against cardiomyocytes injury via inhibiting endoplasmic reticulum and mitochondrial stress pathways. Heart Vessels 2. Jin, Q., Zhou, J., Zhang, N., Lin, C. J., Pang, Y., Gu, G., Shen, W. F. and Wu, L. Q. (2012) Ibutilide decreases defibrillation threshold by the reduction of activation pattern complexity during ventricular fibrillation in canine hearts. Chin Med J (Engl). 125, 2701-2707 | |
Quality Control & MSDS
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Chemical structure
