IGF-1, human recombinant
Insulin-like growth factor I (IGF-1) is a polypeptide endocrine hormone structurally similar to insulin and is mainly produced in the liver when stimulated by growth hormone. IGF-1 is a growth factor that stimulates the proliferation of various cell types including muscle, bone, and cartilage tissue. IGF-1 binds and interacts with the IGF-1 binding proteins (IGFBPs). IGF-1 binds to the IGF-1 receptor with a higher affinity than the insulin receptor.
Human IGF-I is synthesized as two precursor isoforms with N- and alternate C-terminal propeptides, which are proteolyzed to produce the identical 7.6 kDa mature IGF-I. Mature human IGF I shares 94% and 96% aa sequence identity with mouse IGF1 and rat IGF1, respectively, and exhibits cross species activity. Human IGF-1 is a 7.6 kDa protein containing 70 amino acid residues. The recombinant human IGF-1 was produced using animal origin free technology.
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| Determined using dose dependent stimulation of Balbc 3T3 cell line. | ||||||
| ED50 | 21.6-54.7 ng/ml. | |||||
Quality Control & DataSheet
- View current batch:
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Purity: ≥98%, by SDS-PAGE and HPLC.
Endotoxin Level:<0.1 ng/μg
Related Biological Data
Related Biological Data
Related Biological Data
Related Biological Data
| Gene ID: | 3479 | Accession #: | P05019 |
| Alternate Names: | IGF1A, Insulin-Like Growth Factor 1, Somatomedin C, IGF-I, IGFI, IGF1, IGF-IA, Mechano growth factor, MGF. | ||
| Source: | Escherichia Coli. | M.Wt: | 7.6 kDa |
| Appearance: | Lyophilized powder | Storage: | Store at -20°C |
| Formulation: | Lyophilized with no additives. | ||
| Solubility: | Reconstitute in water to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 4℃ for 1 week or -20℃ for future use. | ||
| Shipping Condition: | Gel pack. | Handling: | Centrifuge the vial prior to opening. |
| Usage: | For Research Use Only! Not to be used in humans. | ||