Latrunculin B
Latrunculin B is a cell-permeable actin polymerization inhibitor in vitro and in vivo by the formation of a 1:1 complex with monomeric G-actin[1].
Although the activity of latrunculin B is slightly weaker than latrunculin A, its short-term effect is comparable to latrunculin A. The presence of serum in the medium always containing latrunculin B gradually causes the inactivation of latrunculin B, so that the induced changes are instantaneous. Because of this, latrunculin B may produce fewer undesirable physiological effects than latrunculin A, making it more suitable for short-term studies[2].
References:
[1]. Wakatsuki T, Schwab B, Thompson N C, et al. Effects of cytochalasin D and latrunculin B on mechanical properties of cells. Journal of Cell Science, 2000, 114(5): 1025-1036.
[2]. Spector I, Schochet N R, Blasberger D, et al. Latrunculins-novel marine macrolides that disrupt microfilament organization and affect cell growth: I. comparison with cytochalasin D. Cell Motility and the Cytoskeleton, 1989, 13(3): 127-144.
| Physical Appearance | Colourless film |
| Storage | Store at -20°C |
| M.Wt | 395.5 |
| Cas No. | 76343-94-7 |
| Formula | C20H29NO5S |
| Solubility | ≤25mg/ml in DMSO |
| Chemical Name | 4R-[(1R,4Z,8Z,10S,13R,15R)-15-hydroxy-5,10-dimethyl-3-oxo-2,14-dioxabicyclo[11.3.1]heptadeca-4,8-dien-15-yl]-2-thiazolidinone |
| SDF | Download SDF |
| Canonical SMILES | C/C(CC/C=C\[C@@H](C)CC[C@@H]1C[C@@H]2C[C@@]([C@H]3N([H])C(SC3)=O)(O)O1)=C/C(O2)=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Purity ≥ 97.00%
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Chemical structure
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