Meclizine 2HCl
Catalog No.
B1786
Histamine H1 receptor antagonist
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Meclizine is a histamine H1 receptor antagonist used to treat nausea and motion sickness, has anti-histamine, anti-muscarinic and anti-oxidative phosphorylation properties, also an agonist ligand for mCAR (constitutive androstane receptor) and an inverse
- 1. Shuhua Shan, Caihong Wu, et al. "Inhibitory Effects of Peroxidase from Foxtail Millet Bran on Colitis-Associated Colorectal Carcinogenesis by the Blockage of Glycerophospholipid Metabolism." Journal of Agricultural and Food Chemistry 2020, 68, 31, 8295–8307;July 13, 2020. PMID:32657580
- 2. Zhu J, Li P, et al. "Altered Energy Metabolism During Early Optic Nerve Crush Injury: Implications of Warburg-Like Aerobic Glycolysis in Facilitating Retinal Ganglion Cell Survival." Neurosci Bull. 2020;10.1007/s12264-020-00490-x. PMID:32277382
- 3. Jingyi Zhu, Ping Li, et al. "Altered energy status during the early optic nerve crush injury: Implications of Warburg-like aerobic glycolysis facilitating RGC survival." EBioMedicine.2018.
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 463.87 |
| Cas No. | 1104-22-9 |
| Formula | C25H27Cl2N2·2HCl |
| Solubility | insoluble in H2O; ≥2.93 mg/mL in EtOH with ultrasonic; ≥48.9 mg/mL in DMSO with ultrasonic |
| Chemical Name | 1-[(4-chlorophenyl)-phenylmethyl]-4-[(3-methylphenyl)methyl]piperazine;dihydrochloride |
| SDF | Download SDF |
| Canonical SMILES | CC1=CC(=CC=C1)CN2CCN(CC2)C(C3=CC=CC=C3)C4=CC=C(C=C4)Cl.Cl.Cl |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
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