ML-095 (hydrochloride)
ML-095 (hydrochloride) is a specific PLAP inhibitor [1].
Alkaline phosphatases are hydrolase enzymes responsible for removing phosphate groups from many types of molecules, including nucleotides, proteins, and alkaloids. There are three isozymes of alkaline phosphatases: placental alkaline phosphatase (PLAP), intestinal alkaline phosphatase (IAP), and tissue non-specific alkaline phosphatase (TNAP). Placental alkaline phosphatase (PLAP) is highly expressed in primate placental tissue and the biological function is still unknown. However, PLAP-like enzymes are detected in serum of patients with primary testicular tumors, in particular seminoma and other cancers [1].
ML-095 (CID-25067483) is a biochemical inhibitor of PLAP and will be useful to elucidate the key biological functions and natural substrates of human PLAP. ML095 is a specific PLAP inhibitor and inhibited PLAP, TNAP and IAP with IC50 values of 2.1, >100 and 53 μM, respectively. ML095 exhibited greater than 25-fold selectivity over tissue non-specific alkaline phosphatase (TNAP) and intestinal alkaline phosphatase (IAP) [1].
Reference:
[1]. Lanier M, Cashman J, Sergienko E, et al. Placental Alkaline Phosphatase (PLAP) Luminescent HTS assay - Probe 2.
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 282.7 |
| Cas No. | 1135318-57-8 |
| Formula | C13H14N2O3·HCl |
| Synonyms | CID-25067483 |
| Solubility | ≤10mg/ml in DMSO |
| Chemical Name | 1-(3,4-dihydroxyphenyl)-2-(2-ethyl-1H-imidazol-1-yl)-ethanone, monohydrochloride |
| SDF | Download SDF |
| Canonical SMILES | OC1=CC=C(C(CN2C=CN=C2CC)=O)C=C1O.Cl |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
- Datasheet
Chemical structure
