Orexin A (human, rat, mouse)
Orexin A, a 33 amino acid hypothalamic neuropeptide, is an endogenous agonist at orexin-1 and -2 receptors[1]. It play a role in appetite regulation, wakefulness, locomotor activity, hypothalamic-pituitary-adrenal activity, and pain thresholds[2].
Orexin A (10 and 30 mg/kg i.v., 5 min pre-plantar test) increases the latency to thermally stimulated paw contraction to baseline levels. Orexin A (3-30 mg/kg; i.v.; 5 min pre-test) significantly increases the reaction latency of intravenous reactions of 10 and 30 mg/kg[3].
References:
[1]. Rodgers R J, Ishii Y, Halford J C G, et al. Orexins and appetite regulation. Neuropeptides, 2002, 36(5): 303-325 .
[2]. Lang M, Söll R M, Dürrenberger F, et al. Structure-activity studies of orexin A and orexin B at the human orexin 1 and orexin 2 receptors led to orexin 2 receptor selective and orexin 1 receptor preferring ligands. Journal of Medicinal Chemistry, 2004, 47(5): 1153-1160.
[3]. Bingham S, et al. Orexin-A, an hypothalamic peptide with analgesic properties. Pain, 2001, 92(1-2): 81-90.
| Physical Appearance | A crystalline solid |
| Storage | Desiccate at -20°C |
| M.Wt | 3565.14 |
| Cas No. | 205640-90-0 |
| Formula | C152H247N47O44S4 |
| Solubility | ≥50.4 mg/mL in DMSO; ≥12.4 mg/mL in EtOH with ultrasonic; ≥50.7 mg/mL in H2O |
| SDF | Download SDF |
| Canonical SMILES | CC[C@]([C@@](/N=C(O)/C/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/C/N=C(O)/[C@](/N=C(O)/C/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O) |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
