Parathyroid hormone (1-34) (human)
Parathyroid hormone (1-34) (human), (C181H291N55O51S2), a peptide with the sequence H2N-SVSEIQLMHNLGKHLNSMERVEWLRKKLQDVHNF-OH, MW= 4117.72. Parathyroid hormone (PTH), parathormone or parathyrin, is secreted by the chief cells of the parathyroid glands as a polypeptide containing 84 amino acids. It acts to increase the concentration of calcium (Ca2+) in the blood, whereas calcitonin (a hormone produced by the parafollicular cells (C cells) of the thyroid gland) acts to decrease calcium concentration. PTH acts to increase the concentration of calcium in the blood by acting upon the parathyroid hormone 1 receptor and the parathyroid hormone 2 receptor(1). Parathyroid hormone regulates serum calcium, It enhances the release of calcium from the large reservoir contained in the bones(2). It enhances active reabsorption of calcium and magnesium from distal tubules and the thick ascending limb(3). It enhances the absorption of calcium in the intestine by increasing the production of activated vitamin D.
Figure1 Formula of Parathyroid hormone (1-34) (human)
Figure2 The parathyroid hormone (PTH) System
Ref:
1. Bieglmayer C, Prager G, Niederle B (October 2002). "Kinetic analyses of parathyroid hormone clearance as measured by three rapid immunoassays during parathyroidectomy". Clin. Chem. 48 (10): 1731–8.
2. PooleK, Reeve J (2005). "Parathyroid hormone - a bone anabolic and catabolic agent". Curr Opin Pharmacol 5 (6): 612–7.
3. Coetzee M, Kruger MC (May 2004). "Osteoprotegerin-receptor activator of nuclear factor-kappaB ligand ratio: a new approach to osteoporosis treatment?". South. Med. J. 97 (5): 506–11.
- 1. Yuefu Chen, Shuxin Sun, et al. "Low-intensity pulsed ultrasound and parathyroid hormone improve muscle atrophy in estrogen deficiency mice." Ultrasonics. 2023 Jul:132:106984. PMID: 36944299
- 2. Qi Lou, Kaizheng Jiang, et al. "The RIG-I-NRF2 axis regulates the mesenchymal stromalniche for bone marrow transplantation." Blood. 2022 Mar 8;blood.2021013048. PMID: 35259210
- 3. Ziyue Qin, Shu Hua, et al. "Parathyroid hormone promotes the osteogenesis of lipopolysaccharide-induced human bone marrow mesenchymal stem cells through the JNK MAPK pathway." Biosci Rep. 2021 Aug 27;41(8):BSR20210420. PMID: 34350461
- 4. Zhiyuan Zou, Le Wang, et al. "Simultaneous incorporation of PTH (1–34) and nano-hydroxyapatite into Chitosan/Alginate Hydrogels for efficient bone regeneration." Bioact Mater. 2020 Dec 7;6(6):1839-1851. PMID: 33336115
- 5. Yuli Wang, Lintong Huang, et al. "Parathyroid hormone ameliorates osteogenesis of human bone marrow mesenchymal stem cells against glucolipotoxicity through p38 MAPK signaling." IUBMB Life. 2021 Jan;73(1):213-222. PMID: 33249758
- 6. Ge X, Li Z, et al. "Parathyroid hormone enhances the osteo/odontogenic differentiation of dental pulp stem cells via ERK and P38 MAPK pathways." J Cell Physiol. 2020 Feb;235(2):1209-1221. PMID: 31276209
| Physical Appearance | A solid |
| Storage | Desiccate at -20°C |
| M.Wt | 4117.75 |
| Cas No. | 52232-67-4 |
| Formula | C181H291N55O51S2 |
| Synonyms | Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Phe |
| Solubility | ≥399.3 mg/mL in DMSO; insoluble in EtOH; ≥19.88 mg/mL in H2O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Cell experiment:[1] | |
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Cell lines |
Human kidney 293 cells stably transfected with the human parathyroid hormone (PTH)/PTH-related protein (PTHrP) receptor |
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Reaction Conditions |
0 ~ 1000 nM |
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Applications |
PTH (1-34) bound to the PTH/PTHrP receptor with an IC50 value of 2 nM. Moreover, PTH (1-34) stimulated inositol phosphate synthesis (≥ 24 nM) and cAMP production (IC50 = 0.22 nM) in 293 cells stably transfected with the PTH/PTHrP receptor. |
| Animal experiment:[1] | |
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Animal models |
Male Fisher 344 rats, 4 weeks old |
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Dosage form |
10 or 40 μg/kg/day Once daily by subcutaneous route for 1, 2, or 4 weeks |
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Applications |
Trabecular and cortical bone mass showed a dose- and time-dependent increase in the treated animals compared with the controls. These increases were evident as early as 1 week after initiation of dosing. |
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Note |
The technical data provided above is for reference only. |
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References: 1. Frolik CA, Cain RL, Sato M, et al. Comparison of recombinant human PTH(1-34) (LY333334) with a C-terminally substituted analog of human PTH-related protein(1-34) (RS-66271): In vitro activity and in vivo pharmacological effects in rats. Journal of Bone and Mineral Research, 1999, 14(2): 163-172. |
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Quality Control & MSDS
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Chemical structure
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