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ReACp53

ReACp53

Catalog No.

B6198

inhibit p53 amyloid formation

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Grouped product items
Size	Price	Stock
1mg	$166.00	Ship with 10-15 days
5mg	$497.00	Ship with 10-15 days
10mg	$744.00	Ship with 10-15 days
25mg	$1,323.00	Ship with 10-15 days
50mg	$2,150.00	Ship with 10-15 days

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Email: [email protected]

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Background
Chemical Properties
Quality Control

Background

ReACp53 is an inhibitor of p53 amyloid formation.

Nearly half of all human cancers lose p53 function by missense mutations, with an unknown fraction of these containing p53 in a self-aggregated amyloid-like state.

In vitro: Previous study found that ReACp53 could penetrates into HGSOC primary cancer cells and convert mutant p53 from a punctate state into soluble wild-type-like p53. ReACp53 could also induce cell-dycle arrest, cancer cell death, resulting in p53 Degradation. Moreover, ReACp53 induced quich cell death in human primary uterine fibroblasts transfected with a R175H p53 mutant. In addition, ReACp53 was found to be able to specifically reduce the cell viability and proliferation of cancer cells with mutant but not wild-type p53 [1].

In vivo: Animal study showed that i.p. administered ReACp53 could rapidly enter the systemic circulation and could be detected in the mouse serum at the 1-hr time point. In addition, ReACp53 could be detected in tumor tissue. In efficacy models, tumor volumes monitored daily suggested that only ReACp53-treated OVCAR3 xenografts shrank whereas vehicle-treated tumors grew more than doubled in size. Moreover, mutant p53-bearing tumors in the ReACp53-treated mice were 80%–90% smaller in weight than the control cohort, further confirming the ability of ReACp53 to inhibit tumor proliferation in vivo [1].

Clinical trial: Up to now, ReACp53 is still in the preclinical development stage.

Reference:
[1] Soragni A et al. A Designed Inhibitor of p53 Aggregation Rescues p53 Tumor Suppression in Ovarian Carcinomas. Cancer Cell. 2016 Jan 11;29(1):90-103.

Chemical Properties

Storage	Store at -20°C
M.Wt	2617.13
Cas No.	N/A
Formula	C₁₀₈H₂₀₆N₅₂O₂₄
Solubility	Soluble in DMSO
Chemical Name	(S)-2-((Z)-((1Z,3S,4Z,6S,7Z,9S,10Z,12S,13Z,15S,16Z,18S,19Z,21S)-3,15-di((S)-sec-butyl)-1-((S)-1-((6S,7Z,9S,10Z,12S,13Z,15S,16Z,18S,19Z,21S,22Z,24S,25Z,27S,28Z,30S,31Z,33S)-1,6-diamino-9,12,15,18,21,24,27,30,33-nonakis(3-guanidinopropyl)-7,10,13,16,19,22,2
SDF	Download SDF
Canonical SMILES	CC[C@]([C@@](/N=C(O)/[C@]1([H])CCCN1C([C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@](N)([H])CCCNC(N)=N)([H])CCCNC(N)=N)([H])CCCNC(N)=N)([H])CCCNC(N)=N)([H])CCCNC(N)=N)([H])CCCNC(N)
Shipping Condition	Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips	We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Quality Control & MSDS

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Purity = 98.00%

Chemical structure

ReACp53

mRNA synthesis

Tyramide Signal Amplification (TSA)

Phos Binding Reagent Acrylamide

Cell Counting Kit-8 (CCK-8)

Inhibitor Cocktails

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Quality Control & MSDS

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