Recombinant Mouse M-CSF/CSF1

Macrophage Colony Stimulating Factor(M-CSF), also known as CSF-1, is a four-alpha -helical-bundle cytokine that is the primary regulator of macrophage survival, proliferation and differentiation ^[1-3]. M-CSF protein is also essential for the survival and proliferation of osteoclast progenitors ^{[1, 4]}. M-CSF also primes and enhances macrophage killing of tumor cells and microorganisms, regulates the release of cytokines and other inflammatory modulators from macrophages, and stimulates pinocytosis ^{[2, 3]}. M-CSF increases during pregnancy to support implantation and growth of the decidua and placenta ^[5]. Sources of M-CSF include fibroblasts, activated macrophages, endometrial secretory epithelium, bone marrow stromal cells and activated endothelial cells ^[1-5]. The M-CSF receptor (c-fms) transduces its pleotropic effects and mediates its endocytosis. The first 229 aa of mature mouse M-CSF shares 87%, 83%, 82% and 81% aa identity with corresponding regions of rat, dog, cow and human M-CSF, respectively ^{[6, 7]}. Human M-CSF is active in the mouse, but mouse M-CSF is reported to be species-specific.

Reference

[1]. Pixley, F.J. and E.R. Stanley (2004) Trends Cell Biol. 14:628.

[2]. Chitu, V. and E.R. Stanley (2006) Curr. Opin. Immunol. 18:39.

[3]. Fixe, P. and V. Praloran (1997) Eur. Cytokine Netw. 8:125.

[4]. Ryan, G.R. et al. (2001) Blood 98:74.

[5]. Makrigiannakis, A. et al. (2006) Trends Endocrinol. Metab. 17:178.

[6]. DeLamarter, J.F. et al. (1987) Nucleic Acids Res. 15:2389.

[7] Ladner, M.B. et al. (1988) Proc. Natl. Acad. Sci. USA 85:6706.