Home >> Signaling Pathways >> Apoptosis >> Caspase

Caspase

Caspases (cysteine-dependent aspartate specific ptotease) are a family of cysteine proteases that play an essential role in cell apoptosis. Caspases contain a conserved QACXG pentapeptide active site motif and are characterized by specificity for aspartic acid in the P1 position. The synthesis of caspases involves the activation of inactive proenzymes, which contain an N-terminal peptide (prodomain) together with two subunits (one small and one large), following cleavage at specific aspartate cleavage sites. Caspases can be classified into three subfamilies, due to phylogenetic analysis, including an ICE subfamily (caspases-1, -4 and -5), a CED-3/CPP32 subfamily (caspases-3, -6, -7, -8, -9 and -10) and an ICH-1/Nedd2 subfamily (caspase-2).

Research Area
Compare Products

  1. Cat.No. Product Name Information
  2. A1902 Z-VAD-FMK

    Cell-permeable, irreversible pan-caspase inhibitor. Inhibits caspase processing and apoptosis induction in tumor cells in vitro (IC50 = 0.0015 - 5.8 mM). Active in vivo.

  3. C5667 Se-Aspirin
  4. C4981 Z-Asp-CH2-DCB
  5. C5528 Ac-DEVD-CMK
  6. C5524 Ac-DEVD-AFC
  7. C4468 NS3694
  8. A8955 Z-YVAD-FMK Z-YVAD-FMK is a potent cell-permeable and irreversible inhibitor of caspase-1.
  9. A9901 Caspase Inhibitor Set I Contains 25µl (10mM) each of the following inhibitors: A1902 Z-VAD-FMK, A1901 Q-VD-OPH, A1920 Z-DEVD-FMK,A8321 Cisplatin
  10. A1925 Caspase-3/7 Inhibitor I A potent, cell-permeable, and specific, reversible inhibitor of caspase-3 (Ki = 60 nM) and caspase-7 (Ki = 170 nM).
  11. A1901 Q-VD-OPh hydrate Q-VD-OPH is a selective, brain and cell permeable, highly potent and irreversible inhibitor of caspase-3 ( IC50=25nm), caspase-1 (IC50=50nM), caspase-8 (IC50=100nM) and caspase-9 (IC50=430nM).

Items 1 to 10 of 32 total

per page
  1. 1
  2. 2
  3. 3
  4. 4

Set Descending Direction