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MTH1

MTH1 (human MutT homolog 1) is an antimutagenic purine nucleoside triphosphatase that sanitize oxidized nucleotide pools. It protects the cell from oxidative stress-induced cell dysfunction or death. It is a target for anticancer treatment.

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  1. Cat.No. Product Name Information
  2. A8802 (S)-Crizotinib (S)-crizotinibthe selectively inhibited MTH1 catalytic activity with IC50 of 72 nM, while clinically used (R)-enantiomer of the drug was inactive with IC50 of 1375 nM.
  3. B5849 TH287 TH287 is a potent MTH1 inhibitor with IC50 of 0.8±0.1 nM. [1]
  4. B5845 TH588 TH588 is a potent and selective MTH1 inhibitor (IC50 = 5 nM)
  5. B4935 SCH 51344

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