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Chromatin/Epigenetics

Epigenetics

Epigenetics means above genetics. It determines how much and whether a gene is expressed without changing DNA sequences. Epigenetic regulations include, 1. DNA methylation: the addition of methyl group to DNA, converting cytosine to 5-methylcytosine, mostly at CpG sites; 2. Histone modifications: posttranslational modificationEpigeneticss of histone proteins including acetylation, methylation, ubiquitylation, phosphorylation and sumoylation; 3. miRNAs: non-coding microRNA downregulating gene expression; 4. Prions: infectious proteins viewed as epigenetic agents capable of inducing a phenotype without changing the genome.

Products for  Chromatin/Epigenetics

product-structure
  1. Cat.No. Product Name Information
  2. A8181 (-)-JQ1 BET bromodomain inhibitor
  3. B7679 (R)-(+)-Etomoxir sodium salt carnitine palmitoyltransferase I (CPT1) inhibitor
  4. B7718 (R)-PFI 2 hydrochloride SETD7 histone lysine methyltransferase inhibitor
  5. C4834 (S)-PFI-2 (hydrochloride) Negative control of (R)-PFI 2 hydrochloride
  6. A4510 1,2,3,4,5,6-Hexabromocyclohexane JAK2 tyrosine kinase inhibitor
  7. C4119 2',3',5'-triacetyl-5-Azacytidine prodrug form of 5-azacytidine, a DNA methyltransferase inhibitor
  8. B5972 2,4-Pyridinedicarboxylic Acid Histone LSD inhibitor
  9. C4445 2-D08 Sumoylation inhibitor
  10. B5969 2-hexyl-4-Pentynoic Acid Potent and robust HDACs inhibitor
  11. A4188 2-Methoxyestradiol (2-MeOE2) Apoptotic, antiproliferative and antiangiogenic agent

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