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PARP

Poly (ADP-ribose) polymerases (PARPs) is a large family of proteins with a conserved catalytic domain that catalyze an immediate DNA-damage-dependent post-translational modification of histones and other nuclear proteins leading to the survival of injured proliferating cells. So far, a total number of 18 human PARP proteins encoded by different genes have been identified, including PARP-1 to PARP-4, PARP-5a, PARP-5b, PARP-5c and PARP-6 to PARP-16. The general structural of PARP proteins has been revealed through the extensive study of the founding family member PARP-1, which is characterized by the presence of four functional domains, including a DNA-binding domain, a caspase-cleaved domain, an automodification domain and a catalytic domain.

product-structure
  1. Cat.No. Product Name Information
  2. A4524 4-HQN PARP inhibitor
  3. A4160 A-966492 PARP-1/-2 inhibitor, highly potent
  4. A3002 ABT-888 (Veliparib) Potent PARP inhibitor
  5. A4158 AG-14361 Potent PARP1 inhibitor
  6. A4164 AZD2461 Novel PARP inhibitor
  7. A4153 BMN 673 Potent PARP inhibitor
  8. A3246 BMN-673 8R,9S PARP inhibitor
  9. A4525 BYK 204165 PARP-1 inhibitor,potent and selective
  10. A4526 BYK 49187 Potent PARP-1/PARP-2 inhibitor
  11. A4527 DR 2313 PARP inhibitor

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