Ropivacaine HCl

Catalog No.

B2023

Sodium channel inhibitor

Grouped product items
Size	Price	Stock
10mM (in 1mL H2O)	$50.00	In stock
Evaluation Sample	$30.00	In stock
50mg	$68.00	In stock

For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Background

Ropivacaine HCl is an anaesthetic agent and blocks impulse conduction in nerve fibres through inhibiting sodium ion influx reversibly.

Physical Appearance	A solid
Storage	Store at -20°C
M.Wt	310.86
Cas No.	98717-15-8
Formula	C₁₇H₂₆N₂O·HCl
Solubility	≥10.1 mg/mL in H2O; ≥42.6 mg/mL in DMSO; ≥50.2 mg/mL in EtOH
Chemical Name	(2S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide;hydrochloride
SDF	Download SDF
Canonical SMILES	CCCN1CCCCC1C(=O)NC2=C(C=CC=C2C)C.Cl
Shipping Condition	Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips	We do not recommend long-term storage for the solution, please use it up soon.

Cell experiment [1]:
Cell lines	SW620 cells
Preparation method	This compound is soluble in DMSO. General tips for obtaining a higher concentration: Please warm the tube at 37℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months.
Reacting condition	0-1000 μM
Applications	In SW620 cells, Ropivacaine concentration-dependently inhibited SW620 invasion through Matrigel with IC50 value of 3.8 μM.
Animal experiment [2]:
Animal models	male NMRI mice
Dosage form	65 and 650 μM; intrascrotal injection
Application	In male NMRI mice, Ropivacaine (650 μM) dose-dependently reduced TNF-a-induced leukocyte adhesion by 63%. Ropivacaine (650 μM) also abolished tissue accumulation of leukocytes in response to TNF-a activation by 79%.
Other notes	Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal.
References: [1]. Baptista-Hon DT1, Robertson FM1, Robertson GB1, et al. Potent inhibition by ropivacaine of metastatic colon cancer SW620 cell invasion and NaV1.5 channel function. Br J Anaesth. 2014 Jul;113 Suppl 1:i39-i48. [2]. Zhang XW1, Thorlacius H. Inhibitory actions of ropivacaine on tumor necrosis factor-alpha-induced leukocyte adhesion and tissue accumulation in vivo. Eur J Pharmacol. 2000 Mar 24;392(1-2):R1-3.

Purity = 99.85%