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In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Animal models
Dogs infected by oesophageal spirocercosis
Dosage form
0.5 mg/kg (p.o.),once daily for 42 days
Application
After 42 days, nodules in 13 dogs subsided. After another 42 days of treatment, 5 of the remaining 7 dogs eliminated nodules. In the remaining two dogs, treatment continued for another 42 days (a total of 126 days), which completely resolved the problem. No adverse events related to treatment were observed. This study concluded that doramectin at 0.5 mg / kg once a day was effective in eliminating Spirocerca lupi in dogs.
Other notes
Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal.
References:
[1]. Lobetti R. Successful resolution of oesophageal spirocercosis in 20 dogs following daily treatment with oral doramectin. Vet J. 2012 Jul;193(1):277-8. doi: 10.1016/j.tvjl.2011.09.002. Epub 2011 Oct 14. PMID: 22000593.