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In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Animal models
Male Wistar rats
Dosage form
10,50 and 400 mg/kg(i.v.)
Application
Cefoselis appeared in the extracellular fluid of the brain in a dose-dependent manner, which was proportional to the concentration in the blood. The elimination constant of brain extracellular fluid (apparent) was slightly lower than that of blood. In rats with renal insufficiency, the elimination half-lives of cefoselis from both blood and brain were extensively prolonged.
Other notes
Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal.
References:
[1]. Ohtaki K, Matsubara K, Fujimaru S, Shimizu K, Awaya T, Suno M, Chiba K, Hayase N, Shiono H. Cefoselis, a beta-lactam antibiotic, easily penetrates the blood-brain barrier and causes seizure independently by glutamate release. J Neural Transm (Vienna). 2004 Dec;111(12):1523-35. Epub 2004 Jul 7. PubMed PMID:15565489.