CXCL10 also known as IP-10 is belonging to the CXC chemokine family. It is encoded by the CXCL10 gene, and in murine it is also named the CRG-2 gene. The gene was originally identified as an immediate early gene induced in response to macrophage activation. This chemokine elicits its effects by binding to the cell surface chemokine receptor CXCR3. CXCL10 has been shown to be a chemoattractant for activated T-lymphocytes and monocytes/macrophages. It also has other roles, such aspromotion of T cell adhesion to endothelial cells, and inhibition of bone marrow colony formation and angiogenesis. Murine CXCL10 shares approximately 67 % amino acid sequence identity with human CXCL10.
Reference
1. Luster AD, Unkeless JC, Ravetch JV. 1985. Nature. 315:672-6
2. Luster AD, Jhanwar SC, Chaganti RS, et al. 1987. Proc Natl Acad Sci U S A. 84:2868-71
3. Vanguri P, Farber JM. 1990. J Biol Chem. 265:15049-57
4. Booth V, Keizer DW, Kamphuis MB, et al. 2002. Biochemistry. 41:10418-25
5. Dufour JH, Dziejman M, Liu MT, et al. 2002. J Immunol. 168:3195-204
6. Angiolillo AL, Sgadari C, Taub DD, et al. 1995. J Exp Med. 182:155-62.