Serotonin HCl

Serotonin hydrochloride is a monoamine neurotransmitter in the central nervous system and an endogenous 5-HT receptor agonist. Serotonin hydrochloride is also a catechol O-methyltransferase (COMT) inhibitor with a Ki of 44 μM.

It is biochemically derived from tryptophan, and it plays an important role in the regulation of mood, sleep, vomiting, sexuality, and appetite. Several disorders are linked to low levels of serotonin, including depression, migraines, bipolar disorder, and anxiety. Its actions are wiped off primarily by uptake of serotonin from the synapse. Serotonin reuptake can be inhibited with cocaine, MDMA, tricyclic antidepressants, and selective serotonin reuptake inhibitors.

In vitro: Serotonin hydrochloride is a monoamine neurotransmitter in the central nervous system and an endogenous 5-HT receptor agonist. Serotonin hydrochloride can also inhibit catechol O-methyltransferase (COMT), an enzyme causing to modulation the perception of pain, via non-competitive binding to the site bound by catechol substrates with a binding affinity comparable to the binding affinity of catechol itself (Ki= 44 μM). Results demonstrate that addition of 100 μM of Serotonin hydrochloride reduces the reaction velocity of COMT.

In vivo: Serotonin hydrochloride produces robust hypersensitivity comparing to saline-treated controls (p<0.001). Compared to IL-13 receiving vehicle following induction of DSS colitis. Obvious growth in colonic 5-HT content is observed in IL-13 mice receiving Serotonin hydrochloride. 

References:

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2. Shajib MS, et al. Interleukin 13 and serotonin: linking the immune and endocrine systems in murine models of intestinal inflammation. PLoS One. 2013 Aug 28;8(8):e72774.

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