Sulfanilamide
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 172.2 |
| Cas No. | 63-74-1 |
| Formula | C6H8N2O2S |
| Solubility | insoluble in H2O; ≥2.49 mg/mL in EtOH with gentle warming and ultrasonic; ≥7.7 mg/mL in DMSO |
| Chemical Name | 4-aminobenzenesulfonamide |
| SDF | Download SDF |
| Canonical SMILES | C1=CC(=CC=C1N)S(=O)(=O)N |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Cell experiment [1]: | |
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Cell lines |
Plasmodium falciparum |
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Preparation method |
The solubility of this compound in DMSO is ≥7.7 mg/mL. General tips for obtaining a higher concentration: Please warm the tube at 37 ℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months. |
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Reacting condition |
380 uM |
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Applications |
Sulfanilamide moderately inhibits the Plasmodium falciparum growth. |
| Animal experiment [1]: | |
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Animal models |
Male, immunosuppressed Sprague-Dawley rats |
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Dosage form |
100, 10, and 1.0 mg/kg/day |
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Application |
Sulfanilamide effectively inhibited P.carinii infection in immunosuppressed rat model with a concentration of 100.0 mg/kg /day. When the dose of Sulfanilamide was reduced to 10.0 mg/kg/day, P. carinii infection occurred. |
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Other notes |
Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal. |
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References: [1]. Kasekarn W, Sirawaraporn R, Chahomchuen T, Cowman AF, Sirawaraporn W. Molecular characterization of bifunctional hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase from Plasmodium falciparum. Mol Biochem Parasitol. 2004 Sep;137(1):43-53. PubMed PMID: 15279950. [2]. Hughes WT, Killmar J. Monodrug efficacies of sulfonamides in prophylaxis for Pneumocystis carinii pneumonia. Antimicrob Agents Chemother. 1996 Apr;40(4):962-5. PubMed PMID: 8849260; PubMed Central PMCID: PMC163239. |
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Quality Control & MSDS
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Chemical structure
