TBB
Catalog No.
A3861
Casein kinase-2 (CK2) inhibitor
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TBB is a highly selective, ATP/GTP-competitive inhibitor of casein kinase-2 (CK2) (IC50 = 0.9 and 1.6 μM for rat liver and human recombinant CK2 respectively). TBB exhibits modest discrimination between CK2 subunits, with Ki values ranging from 80 nM to 210 nM. TBB acts in an ATP/GTP-competitive manner and displays one to two orders of magnitude selectivity over a panel of 33 protein kinases. The effect of TBB on PC-3 human prostate cancer cell viability depends on the time schedule of administration.
- 1. Yang PM, Hong YH, et al. "Progressive Rotavirus Infection Downregulates Redox-Sensitive Transcription Factor Nrf2 and Nrf2-Driven Transcription Units." Oxid Med Cell Longev. 2020 Apr 4;2020:7289120. PMID:32322337
- 2. Zhao Z, Wang L, et al."Regulation of MLL/COMPASS stability through its proteolytic cleavage by taspase1 as a possible approach for clinical therapy of leukemia." Genes Dev. 2019 Jan 1;33(1-2):61-74. PMID:30573454
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 434.71 |
| Cas No. | 17374-26-4 |
| Formula | C6HBr4N3 |
| Synonyms | NSC 231634; TBB (enzyme inhibitor);1H-Benzotriazole, 4,5,6,7-tetrabromo- |
| Solubility | insoluble in H2O; ≥159.2 mg/mL in DMSO; ≥10.42 mg/mL in EtOH with ultrasonic |
| Chemical Name | 4,5,6,7-tetrabromo-2H-benzotriazole |
| SDF | Download SDF |
| Canonical SMILES | C1(=C(C2=NNN=C2C(=C1Br)Br)Br)Br |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
Related Biological Data
Related Biological Data
