Teicoplanin A2
Teicoplanin A2 is a new glycopeptide antibiotic belonging to the same family as vancomycin. Teicoplanin consists of five major components (A2-1 through A2-5), one hydrolysis component (A3-1), and four minor components (RS-1 through RS-4) [1]. Teicoplanin is isolated from the fermentation broth of Actinoplanes teichomyceticus nov. sp. and has been endowed with outstanding bactericidal activity against grampositive pathogenic bacteria [2].
In vitro: Teicoplanin inhibited cell wall synthesis in Bacillus subtilis, the inhibition is accompanied by an intracellular accumulation of UDP-N-acetyl-muramyl-pentapeptide. In a cell-free system from Bacillus stearothermophilus, treatment with teicoplanin (40 μg/ml) inhibited 50% of peptidoglycan synthesis, and 100 μg/ml teicoplanin totally suppressed peptidoglycan synthesis [2].
In vivo: Following intravenous administration, concentrations of teicoplanin were high in lung and bone tissue and low in fat in relative to those in plasma in patients with normal renal function. Animal data showed high concentrations in most tissues, and particularly high in liver and kidneys [3].
References:
[1] Bernareggi A, Borghi A, Borgonovi M, et al. Teicoplanin metabolism in humans[J]. Antimicrobial agents and chemotherapy, 1992, 36(8): 1744-1749.
[2] S. Somma, L. Gastaldo and A. Corti. Teicoplanin, a new antibiotic from Actinoplanes teichomyceticus nov. sp. Antimicrobial Agents and Chemotherapy 26(6), 917-923 (1984).
[3] Rowland M. Clinical pharmacokinetics of teicoplanin[J]. Clinical pharmacokinetics, 1990, 18(3): 184-209
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| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 1709.39 |
| Cas No. | 61036-64-4 |
| Formula | C78H77Cl2N8O32R |
| Synonyms | Teicoplanin; Teichomycin; Targocid; MDL-507 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
| Cell experiment [1]: | |
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Cell lines |
Bacillus stearothermophilus |
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Preparation method |
The solubility of this compound in DMSO is ≤ 10 mg/ml. General tips for obtaining a higher concentration: Please warm the tube at 37 ℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months. |
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Reacting condition |
40 μg/ml |
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Applications |
Teicoplanin inhibits the cell-free system of Bacillus stearothermophilus capable of synthesizing peptidoglycan at an inhibition concentration of 40 μg/ml at 50% and an inhibition concentration of 100 μg/ml at 100%; inhibition of peptidoglycan synthesis is accompanied by parallel accumulation of lipid intermediates. |
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References: [1]. Somma S, Gastaldo L, Corti A. Teicoplanin, a new antibiotic from Actinoplanes teichomyceticus nov. sp. Antimicrob Agents Chemother. 1984 Dec;26(6):917-23. doi: 10.1128/aac.26.6.917. PMID: 6240963; PMCID: PMC180050. |
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Quality Control & MSDS
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Chemical structure
