Tranylcypromine hydrochloride
Tranylcypromine, also known as 2-PCPA, is a monoamine oxidase inhibitor (MAOI) that irreversibly inhibits MAO A and MAO B with the inhibition constant Ki values of 101.9 μM and 16 μM and the half maximal inhibition concentration IC50 values of 2.3 μM and 0.95 μM respectively [1].
Tranylcypromine has also been found to potently and irreversibly inhibit histone demethylase lysine-specific demethylase 1 (LSD1), which is an amine oxidase homologue of MAO sharing similarities in the catalytic site with MAO A and B, in a time dependent and mechanism based manner with Ki and IC50 values of 242 μM and 20.7 μM respectively [1].
Reference
References:
[1] Schmidt DM, McCafferty DG. trans-2-Phenylcyclopropylamine is a mechanism-based inactivator of the histone demethylase LSD1. Biochemistry. 2007 Apr 10;46(14):4408-16. Epub 2007 Mar 17.
| Physical Appearance | A solid |
| Storage | Desiccate at RT |
| M.Wt | 169.65 |
| Cas No. | 1986-47-6 |
| Formula | C9H11N·HCl |
| Solubility | ≥54.3 mg/mL in H2O; ≥54.9 mg/mL in EtOH; ≥7.8 mg/mL in DMSO |
| Chemical Name | (1R,2S)-2-phenylcyclopropanamine hydrochloride |
| SDF | Download SDF |
| Canonical SMILES | N[C@H]1[C@H](C2=CC=CC=C2)C1.Cl |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
Related Biological Data
