Home
Valdecoxib

Valdecoxib

Catalog No.

B1459

COX-2 inhibitor

Skip to the beginning of the images gallery

Grouped product items
Size	Price	Stock
10mM (in 1mL DMSO)	$50.00	In stock
10mg	$80.00	In stock
50mg	$320.00	In stock

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background
Chemical Properties
Protocol
Quality Control

Background

Valdecoxib is a potent and selective inhibitor of cyclooxygenase-2 (COX-2) with IC50 value of 5nM [1].

Valdecoxib is developed for the management of pain and inflammation. Valdecoxib and its intravenous prodrug parecoxib exert significant opioid-sparing effects after dental, gynecologic, orthopedic and other noncardiac surgical procedures. In the cellular assay, valdecoxib shows inhibitory activity on human recombinant COX-2 with IC50 value of 5nM. It shows no significant effect on COX-1 with IC50 value of 140μM. In the ex vivo assay using human whole blood, valdecoxib prevents PGE2 production with IC50 value of 0.89μM. Moreover, oral administration of valdecoxib exerts chronic anti-inflammatory activity with ED50 value of 0.032 mg/kg/day in the rat adjuvant arthritis model. In addition, valdecoxib is reported to have cardiovascular risk adverse effect in patients undergoing CABG [1, 2].

References:
[1] Talley J J, Brown D L, Carter J S, et al. 4-[5-Methyl-3-phenylisoxazol-4-yl]-benzenesulfonamide, valdecoxib: a potent and selective inhibitor of COX-2. Journal of medicinal chemistry, 2000, 43(5): 775-777.
[2] Nussmeier N A, Whelton A A, Brown M T, et al. Complications of the COX-2 inhibitors parecoxib and valdecoxib after cardiac surgery. New England Journal of Medicine, 2005, 352(11): 1081-1091.

Chemical Properties

Storage	Store at -20°C
M.Wt	314.36
Cas No.	181695-72-7
Formula	C16H14N2O3S
Solubility	insoluble in H2O; ≥15.72 mg/mL in DMSO; ≥5.42 mg/mL in EtOH with ultrasonic
Chemical Name	4-(5-methyl-3-phenyl-1,2-oxazol-4-yl)benzenesulfonamide
SDF	Download SDF
Canonical SMILES	CC1=C(C(=NO1)C2=CC=CC=C2)C3=CC=C(C=C3)S(=O)(=O)N
Shipping Condition	Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips	We do not recommend long-term storage for the solution, please use it up soon.

Protocol

In vitro experiment [1]:
Samples	Whole blood
Preparation method	The solubility of this compound in DMSO is > 10 mM. General tips for obtaining a higher concentration: Please warm the tube at 37 °C for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below - 20 °C for several months.
Reacting condition	Overnight for assessment of the extent of COX-2 inhibition; 25 mins for assessment of the extent of COX-1 inhibition
Applications	In the assay for assessment of the extent of COX-2 inhibition, Valdecoxib inhibited lipopolysaccharide-induced PGE2 production, with an IC50 value of 0.89 μM. In the assay for assessment of the extent of COX-1 inhibition, Valdecoxib inhibited TXB2 production, with an IC50 value of 25.4 μM.
Animal experiment [1]:
Animal models	Male SD rats
Dosage form	0.02, 0.032 or 10.2 mg/kg; p.o.
Applications	In SD rats, Valdecoxib inhibited carrageenan-induced foot pad edema, with an ED50 value of 10.2 mg/kg. In a rat adjuvant arthritis model, Valdecoxib also showed chronic anti-inflammatory activity, with an ED50 value of 0.032 mg/kg/day. In addition, Valdecoxib inhibited prostaglandin production at the inflammatory site in a carrageenan-induced air pouch model, with an ED50 value of 0.02 mg/kg.
Other notes	Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal.
References: [1]. Talley J J, Brown D L, Carter J S, et al. 4-[5-Methyl-3-phenylisoxazol-4-yl]-benzenesulfonamide, valdecoxib: a potent and selective inhibitor of COX-2. Journal of medicinal chemistry, 2000, 43(5): 775-777.

Quality Control

Quality Control & MSDS

View current batch:

Purity = 99.28%

Chemical structure

Valdecoxib

mRNA synthesis

Tyramide Signal Amplification (TSA)

Phos Binding Reagent Acrylamide

Cell Counting Kit-8 (CCK-8)

Inhibitor Cocktails

Background

Chemical Properties

Protocol

Quality Control

Quality Control & MSDS

Chemical structure

Product Catalog

Order Info

Customer Service

Contact Us

Newsletter

Follow Us