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In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Wnt agonist 1 is a small-molecule agonist of Wnt signaling pathway [1].
The Wnt signaling pathway is an important signal transduction pathway that involved in a variety of physiological and pathological processes by regulating genes involved in cellular adhesion, proliferation, and differentiation [1].
Wnt agonist 1 is a cell-permeable Wnt signaling pathway agonist. Wnt agonist 1 induced b-catenin- and TCF-dependent transcriptional activity in a dose-dependent way with EC50 of 0.7 μM. In Xenopus embryos, treatment with Wnt agonist 1 (10 μM) from developmental stage 10.5 to stage 40 resulted in substantial head defects, such as diminished heads and complete loss of eyes, and reduced eyes and heads. This phenotype is similar to that which results from Wnt over-expression in head specification during early embryonic development.
Reference:Liu J, Wu X, Mitchell B, et al. A small-molecule agonist of the Wnt signaling pathway. Angew Chem Int Ed Engl. 2005 Mar 18;44(13):1987-90.