Z-FY-CHO
Catalog No.
A9078
Z-FY-CHO is a potent and specific cathepsin L inhibitor.
Featured Products
Cathepsin L inhibitor is a potent inhibitor of cathepsin L (IC50 = 0.85 nM). lt is selective for cathepsin L over calpain Ⅱ and cathepsin B (IC50s = 184, and 85.1 nM, respectively). lt is trypanocidal with an ED50 value of 45 nM against T. brucei that is well below the ED50 value of 21,500 nM for human HL-60 cells.Cathepsin L inhibitor completely suppresses osteoclastic pit formation on femur slices isolated from bovine cortical bone at a concentration of 1 ug/ml. In vivo, cathepsin L inhibitor (2.5-10 mg/kg) inhibits bone loss in a mousemodel of osteoporosis in a dose-dependent manner.
| Storage | Store at -20°C |
| M.Wt | 446.5 |
| Cas No. | 167498-29-5 |
| Formula | C26H26N2O5 |
| Synonyms | Z-Phe-Tyr-CHO, SB 412515 |
| Solubility | Soluble in DMSO |
| Chemical Name | benzyl ((S)-1-(((S)-1-(4-hydroxyphenyl)-3-oxopropan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate |
| SDF | Download SDF |
| Canonical SMILES | O=C(N[C@@H](CC1=CC=C(O)C=C1)C=O)[C@H](CC2=CC=CC=C2)NC(OCC3=CC=CC=C3)=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
- View current batch:
-
Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
Chemical structure
