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In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Cell lines
Dermatophyte fungi, yeasts, bacteria
Preparation method
The solubility of this compound in DMSO is ≥17.55mg/mL. General tips for obtaining a higher concentration: Please warm the tube at 37 ℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months.
Reacting condition
0.03~0.25 μg/mL
Applications
Butenafine showed limited activity against Candida albicans and no activity against Malassezia furfur. Butenafine is not active against the gram-negative bacteria tested.
Animal models
Male Hartley strain guinea pigs
Dosage form
1%, once a day
Application
Butenafine has a good effect on dermatophyte, and the treatment effect is better than naftifine, tolnaftate, clotrimazole, and bifonazole. Using butenafine 24 or 48 hours before infection can help prevent experimental T. mentagrophytes infection.
Other notes
Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal.
References:
[1]. Kokjohn K, Bradley M, Griffiths B, Ghannoum M. Evaluation of in vitro activity of ciclopirox olamine, butenafine HCl and econazole nitrate against dermatophytes, yeasts and bacteria. Int J Dermatol. 2003 Sep;42 Suppl 1:11-7. PubMed PMID: 12895182.
[2]. Arika T, Yokoo M, Hase T, Maeda T, Amemiya K, Yamaguchi H. Effects of butenafine hydrochloride, a new benzylamine derivative, on experimental dermatophytosis in guinea pigs. Antimicrob Agents Chemother. 1990 Nov;34(11):2250-3. PubMed PMID: 2073116; PubMed Central PMCID: PMC172031.