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In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Digoxin effectively inhibits Na+/K+-ATPase and has the potential to treat arrhythmias and heart failure[1].
Digoxin treatment can reduce CHIKV infection of U-2 OS cells, primary human synovial fibroblasts (HSF), and Vero African green monkey kidney cells. Twenty-four hours after treatment with 1 μM digoxin, cell survival is only moderately compromised, which is 20 times the digoxin EC50 dose of the antiviral activity of CHIKV in these cells [1].
Reference:
[1]. Ashbrook A W, et al. Antagonism of the Sodium-Potassium ATPase Impairs Chikungunya Virus Infection. MBio, 2016, 7(3): e00693-16.
Cell lines
Human osteosarcoma (U-2 OS) cells
Reaction Conditions
0.01 ~ 10 μM digoxin for 1 h incubation
Applications
Treatment of human cells with digoxin resulted in a dose-dependent decrease in infection by chikungunya virus (CHIKV). Inhibition by digoxin was cell type-specific, as digoxin treatment of either murine or mosquito cells did not diminish CHIKV infection.
Animal models
Female mongrel dogs in which the main pulmonary artery had been constricted progressively until cardiac failure developed
Dosage form
1 ~ 1.2 mg
Administered intravenously
Acute digoxin treatment decreased right atrial pressure and increased cardiac output in a canine model of congestive heart failure produced by pulmonary artery constriction
Note
The technical data provided above is for reference only.
References:
1. Ashbrook AW, Lentscher AJ, Zamora PF, et al. Antagonism of the Sodium-Potassium ATPase Impairs Chikungunya Virus Infection. mBio, 2016, 7(3): e00693-16.
2. Davis JO, Howell DS, Hyatt RE. Effects of acute and chronic digoxin administration in dogs with right-sided congestive heart failure produced by pulmonary artery constriction. Circulation Research. 1955, 3(3): 259-263.