JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript in your browser.
Tel: +1-832-696-8203
Email: [email protected]
Worldwide Distributors
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
NB-598 is a potent competitive inhibitor of squalene epoxidase (SE). NB-598 suppresses triglyceride biosynthesis through the farnesol pathway. SE inhibitor NB-598 significantly inhibited both basal and glucose-stimulated insulin secretion from mouse pancreatic islets. CaV channels were markedly inhibited by NB-598.
Cell lines
MIN6 cells, as well as mouse and human pancreatic islets
Reaction Conditions
10 μM NB-598 for 48 h incubation
Applications
Cholesterol reduction of 36 ~ 52% was observed in MIN6 cells, mouse and human pancreatic islets after a 48-h incubation with 10 μM NB-598. A similar reduction in cholesterol was observed in the subcellular compartments of MIN6 cells. In addition, inhibition of cholesterol biosynthesis by NB-598 impaired insulin secretion and voltage-gated calcium channel function in pancreatic beta-cells.
Note
The technical data provided above is for reference only.
References:
1. Xia F, Xie L, Mihic A, et al. Inhibition of cholesterol biosynthesis impairs insulin secretion and voltage-gated calcium channel function in pancreatic beta-cells. Endocrinology, 2008, 149(10): 5136-5145.