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In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Necrostatin 2 (Nec-2) is a novel and potent necroptosis inhibitor with EC50 of 50 nM. It is an analog of necrostatin 1 (nec-1).
Necroptosis is a mechanism of necrotic cell death induced by apoptotic stimuli in the form of death domain receptor engagement by their respective ligands under conditions where apoptotic execution is prevented.
Nec-2 is efficacious in an animal model of ischemic stroke. Many Necroptosis inhibitor derivatives are designed for researchers. There is limited record for Nec-2, but some reports are related with other necrostatins. Nec-1, a small-molecule inhibitor of necroptosis, is also a selective allosteric inhibitor of the death domain receptor-associated adaptor kinase RIP1 in vitro.
Reference:[1]. Teng X, Keys H, Jeevanandam A, Structure-activity relationship study of [1,2,3]thiadiazole necroptosis inhibitors. Bioorg Med Chem Lett. 2007 Dec 15;17(24):6836-40.