JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript in your browser.
Tel: +1-832-696-8203
Email: [email protected]
Worldwide Distributors
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
To investigate the function of macrophages in a complex in vivo environment, depletion experiment can be utilized. Clodronate liposomes are an effective and versatile way to deplete macrophages in vivo. Clodronate liposomes function on the principle of delivering a potent macrophage-depleting agent, clodronate, encapsulated within a lipid bilayer. When administered in vivo, these liposomes are specifically taken up by macrophages through a process known as phagocytosis. Once internalized, the liposomes release clodronate into the macrophage, ultimately resulting in cell death through apoptosis.
PBS liposomes do not contain clodronate, and liposomes contain only PBS, which can be used for control group experiments. This product requires use in conjunction with Clodronate Liposomes (Cat. No. K2721).
Figure 1: Mouse were treated with PBS Liposomes (Cat. Number: K2722) or Clodronate Liposomes (Cat. Number: K2721). Tissue was taken after death for the mouse macrophage maker F4/80 staining. The result showed that Clodronate Liposomes could significantly deplete macrophages