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In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Cell lines
Human B-lymphoma Raji and T-lymphoma Jurkat cell lines
Reaction Conditions
0 ~ 80 nM for 3 or 6 days
Applications
These two lymphoma cell lines were very sensitive to triptonide in a dose-dependent manner, with the IC50 of 11.4 nM at 3 days and 5.7 nM at 6 days in B-lymphoma Raji cells, and 11.1 nM at 3 days and 4.8 nM at 6 days in T-lymphoma Jurkat cells, respectively.
Animal models
Eight-week-old female NOD/SCID mice (18 ~ 22 g) xenografted with Raji cells
Dosage form
5 mg/kg
Once daily by intraperitoneal injection for 34 days
Triptonide at a dose of 5 mg/kg/day almost completely inhibited the lymphoma growth in human lymphoma cells-xenografted mice without obvious side effects. Moreover, the tumors in 6 mice among the 8 xenografted mice were completely eradicated in vivo.
Note
The technical data provided above is for reference only.
References:
1. Yang P, Dong F, Zhou Q. Triptonide acts as a novel potent anti-lymphoma agent with low toxicity mainly through inhibition of proto-oncogene Lyn transcription and suppression of Lyn signal pathway. Toxicology Letters, 2017, 278: 9-17.