HDAC

Histone deacetylases (HDACs), known for their ability to target histones as well as more than 50 non-histone proteins, are classified into three major classes according to their homology to yeast proteins, including class I (HDAC1, HDAC2, HDAC3 and HDAC8), class II (HDAC4, HDAC5, HDAC7 and HDAC9) and class IV (HDAC11). HDAC inhibitors, a large group of compounds that is able to induce the accumulation of acetylated histones as well as non-histone proteins, are divided into several structural classes including hydroxamates, cyclic peptides, aliphatic acids and benzamides. HDAC inhibitors have been investigated for their efficacy as anticancer agents in the treatment of a wild range of cancers.

C5334 BRD6688

Summary: HDAC inhibitor

≤2 mg/mL
C4018 4-iodo-SAHA

Summary: class I and class II histone deacetylase (HDAC) inhibitor

insoluble in H2O; insoluble in EtOH; ≥1.67 mg/mL
B7816 ITSA-1 (ITSA1)

Summary: HDAC activator via Trichostatin A (TSA) suppression

insoluble in H2O; insoluble in EtOH; ≥89 mg/mL
B5969 2-hexyl-4-Pentynoic Acid

Summary: Potent and robust HDACs inhibitor

insoluble in H2O; ≥15.45 mg/mL
B5968 BML-210(CAY10433)

Summary: Novel HDAC inhibitor

insoluble in H2O; ≥10.5 mg/mL
B5967 UF 010

Summary: Novel and selective class I HDAC inhibitor

insoluble in H2O; ≥10.65 mg/mL
B5949 BG45

Summary: Novel HDAC3-selective inhibitor

Soluble in DMSO
B5936 ACY-241

Summary: Selective and orally active HDAC6 inhibitor

≥23.4 mg/mL
B5916 Chidamide
1 Citation

Target: HDAC

Summary: Novel HDAC inhibitor

insoluble in H2O; insoluble in EtOH; ≥18.55 mg/mL
B4890 HPOB
1 Citation

Target: Histone Deacetylases (HDACs)

Summary: HDAC6 inhibitor, potent and selective

≥31.4 mg/mL

HDAC

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